Abstract: The purpose of written review paper on anti-fungal nail lacquer which is used in treatment of Onychomycosis skin fungal disorder was focus on the disease causes and treatment by nail lacquer, onychomycosis causes by the pathogens include dermatophytes, candida, and non-dermatophytes. Improvement clinical efficacy and also proper the patients compliance. Nail Lacquer preparation by simple mixing non-volatile, gloss, smoothness to flow, drug diffusion studies drug content estimation, Nail lacquer is used on fingernails, toenails of the human beings.