Abstract: Perceptions of primary care givers influence adherence to scheduled medical appointments among HIV infected children on HIV Care and treatment, yet there is limited data on how HIV infected children are affected by perception of their primary caregiver on adherence to scheduled medical appointments. Qualitative study was done during the month of November, 2017 using two focused group discussion consisting of 8 participants per group among primary care givers of HIV infected children receiving HIV care and treatment at Comprehensive Care Centre, Kenyatta National Hospital, Kenya.