Abstract: Commercial banks are deemed as an exigent part of the world’s economy. The research paper has been ended up wholly relied on the annual reports of five years data from 2015 to 2019, and some definite data is collected from the annual reports such as return on investment, capital adequacy ratio, cost-income ratio, debt-equity, nonperforming loan. Only the internal factors affecting the commercial bank profitability in Bangladesh is taken up into the account in this study. Some preliminary diagnoses have been used to assess the significance of data, like normality test, autocorrelation test, and heteroskedasticity test. In contrast, some statistical methods, like descriptive analysis, univariate analysis, and multiple regression, have been implemented to concluding the research. The findings show that the cost-income ratio, and debt-equity ratio have been found as a negative relationship with the profitability, whereas the capital adequacy and nonperforming loan have not found any significant relationship with the profitability.