Abstract: The paper examines a case study of a patient with an immunocompromised condition who contracted a respiratory infection caused by Lophomonas Blattarum. Lophomonas Blattarum is a flagellated protozoan commonly found in cockroaches and is known to cause respiratory infections in humans, although it is rare. The paper highlights the clinical manifestations and diagnosis of the infection and the management and treatment strategies used to treat the patient. The study emphasizes the importance of considering Lophomonas Blattarum as a possible cause of respiratory infections, especially in immunocompromised patients. The findings of this study could help healthcare providers improve the diagnosis and management of this rare but potentially fatal infection in immunocompromised patients.