Abstract: Using a Photodiode Array UV detector, researchers were able to develop a simple liquid chromatographic method for analyzing azithromycin in bulk and medicinal dosage forms. In this study, we used a C18 Column with dimensions of 25cm x 4.6mm and L1 packing at 50 + 1°C, a flow rate of 2ml/min, and an injection volume of 100µl each injection. Drugs can be separated quickly and precisely using a mobile phase that has been optimized. This experiment used a flow rate of 1.5 mL/min, a wavelength of 210 nm, and an injection volume of 500 L.