IJSRP, Volume 3, Issue 7, July 2013 Edition [ISSN 2250-3153]
D.S.Ambadkar , R.M.Kedar
Abstract:
In this study new imidazole derivatives were synthesized .The first stage involved preparation of 2-hydroxy-1-(4-methoxyphenyl)-ethan-1-one(C1) by reacting 4-methoxybenzaldehyde with benzaldehyde in presence of sodium cyanide catalyst .The second stage involved the synthesis of 1-(4-methoxyphenyl) -2-phenylethan-1,2-dione(C2) using nitric acid in glacial acetic acid .Finally the compound ( 4a to 4l ) were synthesized using the three-component system ( Compound C2 , Substituted benzaldehyde ,and ammonium acetate) .The structures of all compounds were confirmed by elemental analysis , NMR , IR data and melting point .In conclusion ,this method offer some advantages such as good yield , simple procedure , low cost of chemicals and easy work up .