Abstract: As a result of the limitations of human cognitive skills, judgment, decision-making, and tactical understanding in the use of Unmanned Aerial Vehicles (UAV), there is a need to redesign the current human-computer interface (HCI) for Autopilot control to improve the interaction and communication links between operators and the UAVs. This system displays the information to increase situational awareness; the operator will see everything, interpret it, make appropriate decisions, and have the ability to implement the decision. Multiple interfaces are developed using C’s Graphical User Interface (GUI) capabilities as a simulation environment. Both alternatives will combine buttons and place them in sequential order according to the steps needed to initialize UAVs and flight paths. Usability tests with participants are conducted to measure their performance based on previously determined metrics: the time it takes to train a participant on how to use the interface, the time to complete a task, the number of errors that occur during the task, and the satisfaction level. Based on the simulation results alternatives are redesigned and retested in order to achieve improved performance. An interface that reduces the cognitive workload on an operator to allow better situational awareness of the environment is determined.