Abstract: Introduction: Surgical wound infection is one of the most common nosocomial infections after surgery. The incidence rate of SSI in the surgical stage is relatively high, especially in orthopedic surgery; the incidence can be up to 71%. Surgical site infection after spine surgery usually occurs through direct inoculation during the surgical procedure. Using blood and wound culture as the gold standard also has several obstacles. Due to the above constraints, an alternative marker is needed to diagnose early SSI events. One marker that can be used is the neutrophil-lymphocyte ratio. The use of the neutrophil-lymphocyte balance is relevant and consistent with the pathogenesis of SSI.