Abstract: Chicks infected with Plasmodium gallinaceum were treated with hormones testosterone, DiethyleStilbestirol, Thyroxine and changes in the serum protein content was monitered. In this research work the male and female chicks were taken with different age groups of first week and fourth week. In this study the total protein content during infection was changed. Albumins were decreased and globulins were increased. Total proteins also decreased.