Abstract: Background: Meningitis is a kind of Central nervous system infections that can be associated with high morbidity and mortality rates. The complications of meningitis include brain abscess, deafness, blindness, respiratory failure, seizures, and brain stem herniation due to intracranial hypertension, cortical vein phlebitis, hydrocephalus, coma, and developmental delay. The study aims: Assess the level of nurse's knowledge toward children with meningitis, Find out effectiveness of an educational program on nurse’s knowledge toward children with meningitis, Find out the relationship between nurse’s knowledge toward children with meningitis and their demographic characteristic.