Abstract: Data and information security can be considered one of the most important issues of the 21st century and it is essential to avoid data breaches, decrease the risk of data exposure, and ensure regulatory compliance. Cloud computing is a trending technology in this era. Cloud computing refers to the on-demand availability of digital resources, particularly data storage and computational power, without the user having to manage them directly. Cryptography and steganography can be defined as the most popular techniques that can be used to enhance data and information security inside the cloud. High- level security can be provided when cryptography and steganography are applied together to the cloud platform. Therefore, Hybrid cryptographic algorithms and multilayer steganographic techniques can be combined to develop a security system for efficient and secure data transmission in the cloud to provide availability, integrity, authenticity, confidentiality, and non-repudiation of the data and information. This paper analyzes the performance of cryptographic and steganographic techniques and suggests the best hybrid cryptographic algorithms and multilayer steganographic techniques that can be combined to efficient and secure data transmission in the cloud.