Abstract: Menopause is one of the most significant events in women’s life and brings in a number of physiological changes that affect the life of a woman permanently. Menopause is the permanent cessation of menstruation resulting in the loss of ovarian follicle development. The age at menopause appears to be genetically determined and is unaffected by race, socioeconomic status, age at menarche or number of prior ovulations. Factors that are toxic to ovary often result in earlier age of menopause; for e.g, women who smoke experience an earlier menopause, women who have had surgery on their ovaries, or have had a hysterectomy, despite retention of their ovaries, may also experience early menopause.