Abstract: God has marked everything on this cosmos with a sign or “signature” for their appliance by human beings, the concept of which is known as Doctrine of Signatures. The substances of plant origin like Kidney Beans (Phaseolus vulgaris), Walnut (Juglans regia), Carrot (Daucus carota subsp. sativus), Celery (Apium graveolens), Avocados (Persea americana), Eggplant (Solanum melongena) and Pears (Pyrus spp.), Figs (Ficus carica), Mushroom (Agaricus bisporus), Grapes (Vitis vinifera), Ginger (Zingiber officinale), Sweet Potatoes (Ipomoea batatas), Olives (Olea europaea), Tomato (Solanum lycopersicum), Onions (Allium cepa L.), Grapefruits (Citrus × paradisi), Oranges (Citrus × sinensis), Bananas (Musa spp.), Cucumber (Cucumis sativus) and Brinjal (Solanum melongena), Peanuts (Arachis hypogaea), Adiantum capillus-veneris ,Orchis sp, Eyebright (Euphrasia officinalis), Hedge woundwort (Stachys sylvatica), Liverwort, Lungwort (Pulmonaria officinalis), Spleenwort or Miltwort (Asplenium spp.), Toothwort (Lathraea spp.), Broccoli (Brassica oleracea) , Ginseng (Panax spp.), Melissa officinalis, Antirrhinum majus, Doronicum scorpiodes, Rheum spp., Anastatica hierochuntica, and substances of animal origin like from Sepia species, Tubipora musica (Coral), Lampyris species, Buglossoides arvensis and substances of mineral origin like from Cidaris spp. exhibit doctrine of signatures.