Abstract: Introduction: The huge reliance on medicinal plants in Africa can be attributed to cultural background, low economic levels and poor access to orthodox medications. However, often times, such reliance are accompanied by the challenges of poor evaluation of their safety profiles before commercialization. The present study investigated the effect of ethanolic leaf extract of Parquetina nigrescens (ELEPN) on lipid profile and white blood cell parameters in male Wistar rats, exposed to Phenylhydrazine.